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The most relevant pharmacologic consideration for amoxicillin relating to activity toward S pneumoniae is the time that concentrations at the site of infection exceed the MIC. Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains. Amoxicillin s activity toward S pneumoniae results from its binding to bacterial enzymes that function to maintain the integrity of the cell wall, and are referred to as penicillin-binding proteins PBP.I am on amoxicillin 500 mg 4 times a day for 10 days to treat a tooth infection which will extracted next week. . 1980; 17:908-11. Thus, as resistance increases, MICs rise, and a dosage necessary to maintain a concentration above the MIC also rises. Amoxicillin anti inflammatory. Started taking it on . Matsuura M, Nakazawa H, Hashimoto T et al.15. As these PBP gradually mutate, amoxicillin begins to lose its effectiveness toward disrupting the bacterial cell wall, and the concentration of amoxicillin necessary to kill S pneumoniae increases, resulting in higher MIC values. IDIS 116380 PubMed 6967713. For amoxicillin and other -lactam antibiotics, a drug concentration maintained above the pathogen MIC for at least 40% of the dosing interval correlates with good clinical efficacy. Antimicrob Agents Chemother

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