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. As these PBP gradually mutate, amoxicillin begins to lose its effectiveness toward disrupting the bacterial cell wall, and the concentration of amoxicillin necessary to kill S pneumoniae increases, resulting in higher MIC values. The dosage of Amoxicillin prescribed to each patient will vary. For amoxicillin and other -lactam antibiotics, a drug concentration maintained above the pathogen MIC for at least 40% of the dosing interval correlates with good clinical efficacy.2 .Concomitant use of amoxicillin/clavulanate potassium and oral anticoagulants may increase the prolongation of prothrombin time. Cheap Amoxil without prescription. 7.Amoxicillin s activity toward S pneumoniae results from its binding to bacterial enzymes that function to maintain the integrity of the cell wall, and are referred to as penicillin-binding proteins PBP. The most relevant pharmacologic consideration for amoxicillin relating to activity toward S pneumoniae is the time that concentrations at the site of infection exceed the MIC. . Thus, as resistance increases, MICs rise, and a dosage necessary to maintain a concentration above the MIC also rises. Always follow your physicians instructions and/or the directions on the prescription drug label

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