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. While on the drug these glands shrink by greater than 90% and hence the acne clears dramatically. Hence 70% of their activity is decreased permanently - hence the excellent long term control of acne. On stopping the drug these glands gradually regain function but can only regain 10-30% of their original function after 12-18 months of being off the drug. Im taking the 40mg strongest in case you know anything about it. Over the counter Accutane.. Accutane shrinks the skin sebaceous glands - these are the glands which play a big part in causing acne.Rademaker M. Australasian Journal of Dermatology. . Adverse effects of isotretinoin: A retrospective review of 1743 patients started on isotretinoin. I recently started taking Accutane about 3 weeks ago and using some prescription face-wash all from dermatologist of course, and I was wondering how long it takes to clear away most of the acne? its mostly my face, just a LITTLE on my back/shoulders.Yes there is a very good chance of this. 2010; 514: 248-253

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