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Although no causal link has been established, 1% of patients using oral Isotretinoin usually branded as Accutane/Roaccutane report psychiatric change. Ive tried using different forms of birth control as a form of hormone therapy, but none of those helped either. . Isotretinoin 10mg. Proactiv only worked for a day before it made my skin worse.All of that may sound scary, but just remember that the majority of Isotretinoin users only experience the most common side effects that are easily alleviated with over the counter products and they generally disappear after you stop taking the drug. The active ingredient in Isosupra is Isotretinoin.Ive tried every drug over-the-counter and prescription, wash, cream, diet, pill, -even Proactiv and Accutane, twice! Ive seen general doctors and dermatologists, but nothing they give me is of any help. Hi. Accutane worked for the last month or two after I used it, then my acne came back. Reported problems include feeling very sad, depression, panic attacks, general anxiety disorder and suicidal ideation.. Oral isotretinoin may cause psychiatric problems.

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